Effects of Doxycycline Treatment on Hematological Parameters, Viscosity, and Cytokines in Canine Monocytic Ehrlichiosis

This study aimed to analyze the hematological parameters, blood viscosity, and cytokines of dogs infected by Ehrlichia canis untreated treated with doxycycline. Initially, 47 were examined, 36 suspected have canine monocytic ehrlichiosis, which was confirmed through molecular polymerase chain reaction tests. consisted 25 dogs, 11 being healthy 14 testing positive for E. canis. The divided into experimental groups based on their test results, including a control group (N = 11), without treatment 7), doxycycline 7) at 10 mg/kg dose every 12 h 28 days. Blood samples taken determine cytokine levels. It observed that, regardless treatment, there reduction in total leukocytes lymphocytes eosinophils platelets decreased infections treatment. Monocytes, eosinophils, increased when Regardless dogs’ viscosity lower than uninfected dogs. Infected showed TNF-α IL-1β. There correlation between IL-10 IL-12 eosinophil count correlated In conclusion, treating ehrlichiosis using can increase platelet levels but may also IL-1β monocyte levels, exacerbating inflammation. Therefore, evaluating is important this condition.